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Ramp up Your Late Night Performances: One Pill can be worth Your Partner’s Giggles

Viagra: Some Background Data
Marketed by the pharmaceutical giant Pfizer as the brand Viagra, this drug has long been debated as one of the treatment regimes for erectile dysfunction. Researchers have often debated that certain ingredients in Viagra may actually be acting as placebo, which agonizes the action of this drug. Viagra also serves as one of the most popular drugs used indiscriminately by global populations in an effort to boost sexual performance, thanks to Pfizer’s aggressive global marketing chains.
Reports and surveys as recent as 2013 described an alarming rate of consumption of Erectile Dysfunction drugs like Viagra even by sexually healthy populations, without even bothering to consult physicians on these matters. For population segments which don't belong to any groups of chronically ill beings, regular ingestion might not come as damaging at that instant, but may offer potential problems invisible to the naked eye. Every drug has its own sets of side effects and/or health implications, which are difficult to underline unless unleashed on a massive scale. Another worrying aspect is that side effects are not reported when occurs on an individual level; though early reporting almost always provide the basis for further research and intensive studies.
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It is quite a natural phenomenon that sexual performances tend to decrease as a person grow old; as a matter of fact, the majority of people who come forward with ingenious plans to treat Erectile Dysfunction fall in ‘above 40’ age bracket. In an effort to preserve capabilities of youth, the whole system of well-being is put at stake, knowingly or unknowingly. To even out these, a series of measures have been taken already by concerned authorities.
But they seldom make any difference. For instance, Medical Insurance claims on covering Sex drives at old age have been left out, merely as it has been recognized (and being popularized as well) that decreasing sexual performance at old age is quite natural, and does not need to be treated as cases of Erectile Dysfunction. As a physician was quoted, “A large proportion of older men has lost sexual interest, don’t have a partner or have other illnesses that preclude sexual activity.”
However, as aforementioned, these measures seldom show any observable changes; modest income Medicare beneficiaries scoop up every effort (and underlying costs) to treat their cases as Erectile Dysfunction, which is far from making sense, if above measures are considered.
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Ingredients in Viagra:
Viagra is the marketed name of the compound Sildenafil Citrate, in which Sildenafil serves as the active Ingredients in Viagra. A list of Ingredients in Viagra has been discussed as per their functionalities:

  • Sildenafil Citrate:

This citrate salt of Sildenafil serves as the main functional Ingredients in Viagra. Primarily known for its use I treatment of Erectile Dysfunction, Sildenafil has also proved its application in primary pulmonary hypotension, as a vasodilator agent and urological agent.

  • Microcrystalline Cellulose:

Another chief Ingredients in Viagra, this refined wood pulp, has been used commercially as a bulking agent in food and pharmaceutical industry. Owing to its inert nature, three-dimensional internal bonding (resulting in highly stable crystalline structure), and resistance to reagents and water makes it an ideal additive for pharmaceutical preparations (dry preparations mostly). It has also been approved as an emulsifier, stabilizer and thickening agent within the European Union following extensive tests and trials.

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  • Croscarmellose Sodium:

Another chief Ingredients in Viagra, it is essentially a cross-linked (internally) sodium carboxymethylcellulose used as a disintegrating agent in pharmaceutical formulations like tablets. In the food processing industry, the same finds use as an emulsifier. Cross-linking internally reduces water solubilising properties of this compound, yet can absorb water many times its weight and swell. Superior drug disintegration and dissolution characteristics are bestowed upon this compound on a grand scale, thus improving bioavailability.

  • Anhydrous dibasic calcium phosphate:

It serves as a multi-functional additive; a sustained release matrix can be made possible using this compound’s properties. Besides, this compound has been employed in food processing industry, in pediatric sections in particular, as a dietary supplement in enriched flour, ready to eat breakfast cereals and noodle products.

  • Hypromellose:

Also known as hydroxypropyl methylcellulose (HPMC), this inert, semi-synthetic, viscoelastic polymer is employed on a whole range of commercial products including pharmaceutical preparations like tablets and ophthalmic lubricants. The food processing industry employs HPMC as a suspending agent and emulsifier, and as an alternative to animal gelatin.

  • Magnesium stearate:
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Another chief Ingredients in Viagra, this anti-adhering agent, and the lubricating agent is used extensively in pharmaceutical formulations (capsules, powders, and tablets). Research has confirmed that magnesium stearate cause prolonged release time of active ingredients, though does not have any significant changes on bioavailability.

  • Titanium dioxide:

One of the exclusive mineral additives of Viagra, it offers a wide range of applications from sunscreen to paint and coloring. In fact, of all the coloring agents available, titanium dioxide is marked to be the most inert and non-toxic coloring agent available.

  • Triacetin:

Better known as glycerin triacetate, it is generally a viscous, colorless liquid, and extensively used in food processing and pharmaceuticals industry. Since the United States Food and Drug Administration marked it safe as an additive in these industries, it has been extensively used as a solvent, humectants, and plasticizer in the pharmaceuticals industry. Triacetin is also noted for its presence in the database of Select Committee on GRAS (Generally Recognized as Safe) Substances.

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  • Lactose:

A disaccharide sugar derived from galactose and glucose, it has been a chief component in food processing industry and pharmaceutical industry since the 1960s. Pharmaceutical grade lactose comes as a highly pure state, as per the standards of purity and identity, put down in lactose monographs of leading pharmacopeias of the world. Lactose is used extensively as diluent or fillers in tablets and dry powder inhalation preparations.

  • FD & C Blue Number 2 Aluminum Lake:

An FDA-approved compound; this compound serves as the chief coloring Ingredients in Viagra. As per the Food and Drug Administration regulations, the D&C Blue No. 2 Aluminum Lake is a safe color additive which can be used in pharmaceutical industry and food processing industry.
Why Extensive Knowledge About Ingredients in Viagra Matter?
Every pharmaceutical formulation is blessed with a blend of additives, which, like Viagra, come from a whole range of sources, and perform a wide range of applications. Extensive knowledge regarding these additives serve as a major step in fully understanding how a dosage form would actually work, the potential side effects, and designing strategies and attempts to limit them. Additives, in general, are inert, without contributing much to body functions and/or general mechanism of the active ingredient itself. However, as history has shown, additives can prove to be toxic to some physical systems. Not because of its immediate action, but because of buildup and rapid metabolism.
Generally, all additives put into pharmaceutical formulations are done so with intent to make the product more appealing to consumers. These additives are not subjected to extensive tests regarding what effects they might demonstrate once it builds up inside the human body, and interfere with body functions. Some additives, though inert, can unleash toxic products once metabolized. A clear picture about these additives also defines a way to mitigate any occurrences of additives led toxic outcomes.
On an EndNote:
The United States Food and Drug Administration have serially categorized some of the classes of additives which are used extensively, but limited knowledge is possessed about compounds which belong to these categories:

  • Artificial Sweeteners
  • Refined sugars
  • Monosodium Glutamate (MSG)
  • Sodium Nitrite and Sodium Nitrate
  • BHT and BHA
  • Olestra or Olean
  • Caffeine
  • Partially hydrogenated oils
  • Brominated vegetable oils

These additives may not be toxic by themselves when taken separately, but can be incompatible with other additives used in pharmaceutical preparations, and produce outcomes not desirable by any standards. Moreover, it takes years of research to determine the kind of incompatibilities they offer, the kind of toxicities they pose, and ways to mitigate or even replace them. As an example, Monosodium Glutamate has been shown in studies to pose significant amounts of risk to infants (4 times more risk than adults), despite which it is being used serially in noodle products of Multinational corporations. Be it the lack of research or lack of respect for such surveys, it sets us on a dangerous path to pose a widespread risk of public health, which has unknown consequences.
Coloring agents, in particular, have lured manufacturers to provide an attractive appearance for their products. However, it is one segment of additives which has undergone least amount of researches; it is also the segment where incidents of toxicity reside the most. Coloring agents are frequently derived from organic and inorganic sources, with very little knowledge about these pigments/materials; these are also the most widespread area for adultery, as synthetic colors are quite economical than coloring agents of natural or mineral origin (say).
In a repeat of words, as the FDA has recommended, it is necessary to point out the additives, underlying side effects, and possible interactions with other lifestyle diets and/or drugs from other treatment regimens.

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